In The Great Shelby Holmes, John Watson has just moved to Harlem with his mother after growing up on Army bases. Having moved many times, he is used to making new friends but he has never met someone quite like Shelby Holmes. Shelby is the perfect person to show him around his new and very diverse city and the details she sees and deduces are amazing. Before long, John finds himself helping with a dognapping case and learning how to observe the world around him. Shelby and John complement each other as well as the original Holmes and Watson but with a quirky humor that makes the two their own great detective team.